SOME IMPORTANT QUESTIONS FOR GPAT/NIPER

Expanded Access IND" is the other term for Which IND?    

A.Investigator IND

B.Emergency Use IND

C.Treatment IND

D.All of these,

All of the following are water insoluble alkaloids except

a) ergometrine

b) ergotamine¿

c) ergocristine¿

d) ergocornine

A,

>MORPHINE- mu receptor agonist.

>NALOXONE, NALTREXONE- narcotic antagonists.

>NALBUPHINE-mu antagonist &k receptor agonist.,

BCG vaccine given by Sc route,

MOLECULAR MODELLING SOFTWARES

>Chem3D

>Alchemy

>Sybyl

>Hyperchem

>ChemX

>Discovery studio pro

>CAChe,

Most of the protein amino acids have S-configuration except

a) L-Alanine

b) L-Proline

c) L-Cysteine

d) L-Serine

C,

Which one of the following tetracycline have ADH antagonistic action

a)demeclocycline

b)minocycline

c)doxycycline

d)all,

How many chiral centers are there in Pinene

A.1         

B.2         

C.3         

D.None,

HIV test may be shown NEGATIVE in WINDOW PERIOD although HIV virus present in body. Thus test must be repeated after 6months.,

Mohit@NIPER: Crystal urea causing drugs:

Sulphonamide,

(In high dose:Thiabendazole,Ciprofloxacin,Methanamine,methotrexate),

NAA: Do anticancer and Antihiv drugs from Kokate with special importance to marine sources... NAA registered student wil get this list...,

VNGoyani: Do all the name reaction from Morrison & Boyed and J.march.

Do Stereochemistry from M.& B.

Most of question are on these topics,

Reducing sugars:GALACTOSE,LACTOSE,FRUCTOSE..Non reducing sugars:SUCROSE,TREHALOSE..Width of double helix dna:,

Dificid (fidaxomicin) is a macrolide antibacterial drug indicated for the treatment of Clostridium difficile-associated diarrhea.

,

Pinacol - Pinacolone reaction is an example of

a)acid catalysed

b)base catalysed

c)H2/Pt

d)none

Configuration of Tartaric Acid is

A.3R 3S      

B.3R 2R        

C.2R 3R     

D.None,

Phase inversion temperature is also known as ' HLB' temperature.

Read about cyclodextrins,NDDS,Non-linear pkinetics in Brahmankar.they r very imp,

Read all about AIDS & HIV tests. It's very imp for all exams.

* If HIV test found +ve then this is confirmed by Western Blot Test & Polymerase chai,

FDA 2day approvd Dificid (fidaxomicin) a macrolide antibacterial drug indicated for the treatment of Clostridium difficile-associated diarrhea.,

Curtius reaction is a conversion of

a)acylazide to isocynate

b)isocynate to acylazide

c)nitrile to acid

d)none,

Near IR range is at ( in micron)

A.0.8 - 2          

B.2 - 15            

C.15 - 1000           

D.none,

 US FDA approved Edurant (rilpivirine)for treatment of HIV-1 infection in adults who never took HIV therapy.Do newly approved drugs for NIPER,

NAA: Do all name rxns around 120-130 frm Jerry march.

Also remeber tthe stereochem part very nicely.

If u join NAA NIPER kit all NIPER materials th,

SAMP is an example of _______.

a)chiral auxillary

b)chiral substrate

c)chiral catalyst

d)none,

Indian Pharmacopoeia is published by

-Ministry of Health and Family Welfare

First Edition of Indian Pharmacopoeia was published in

-1955,

Diel's - Alder reaction is an example of

A.Cycloaddition reaction   

B.Pericyclic reaction      

C.Sigmatropic reaction   

D.none of the above,

Hexahelicene shows chirality due to ________.

a)chiral axis

b)helical shape

c)chiral point

d)chiral carbon,

All ______ reactions are ____.

a) stereoselective, stereospecific

b) stereospecific, stereoselective

c) synthetic, asymmetric,

Indian Nobel prize winners

Hargobind Khorana (Nobel Prize in Medicine -1968)

Mother Teresa (Nobel Peace Prize in 1979)

Register for best postal,

The presence of thiophene in benzene is detected by the reaction

a)Howarth

b)indophenin

c)both

d)none,

the glomerular filteration rate is 130ml/min

the amount of body cholesterol 250 mg/dl,

Amorphous substance do not have melting point but glass transition temperature.

ciclosporin is the drug which has 1200 M.W bt absorbed by GIT

UTI work for

a)Mobilization of saving people

b)Provide homes for public

c)both

d) none of these

VNGoyani: Which type of energy bring about U.V transitions

A)Electronic

B)Vibrational

C)Rotational

D) All of the above

NIPERites: Organisms called slime molds have characteristics of both fungi and amoebas.production of mono anti-bodies was first invented by Cesar Mil

sandip: Bombay:

Central Drug Testing Laboratory (CDTL)

Indian Drug Manufacturing Association (IDMA)

National Plasma Fractionation Centre

VNGoyani: A solid of density D is floating in liquid of density d.If v is vol. of solid submerged in liq & V is total vol.of solid.Then v/V=

D/d

In 5HT Recep all r G PROTEIN COUPLED receptors except 5HT3.As 5HT3 is a LIGAND GATED.. 5HT1D,5HT2A AGONIST(METHYSERGIDE)Use:Migraine

Total time required for one cycle of PCR is

a)3 minute

b)10 minute

c)15 minute

d)30 minute

A

IL-1 is called endogenous pyrogen

No of amioacids in insulin is 51

St. johns wart is called hyperforin and it is antideprssant.phenytoin non-lin

 PHOTOCHEMISTRY :-

the reaction which take place whwn molecules absorb ultraviolet or visible radiation are called photochemical reaction.

tertiary protein structurs:-insuline

qurternary:- haemoglobin, enzymes

primary protein structure is linear,all other 3 are non linear

VNGoyani: What is the total number of pi bonds found in the 1-nitro propyne?

a) 1

b) 3

c) 2

d) 4

ans.d

Turbolent flow start when Reynolds' number

-greater than 4000

List principle of all mills n specific use of mills.

VNGoyani: What a Polymer that is which softens upon the absorption of water & is used to make contact lenses?

HARISHARORA

Walden Inversion occurs in

a) SN2 reaction

b) SN1 reaction

c) SNi reaction

d) all.most imp ques being askd almost each year in NIPER exams

GUNTURACADEMY

Rajesh: Rxn in which stereochemically diff molecules react differently-STEREOSPECIFIC RXN..D4 receptor polymorphism-SCHIZOPHRENIA

he concentration of dispersed phase in parentral suspension should be 1-30.

the amount of moisture in acacia nd digitalis is 15 nd 5 % rspective,

study abt DSC,TGA,XRD very briefly.vitamins,PCR,human genome project,monoclonal antibodies,pencillin fermentation,taxol side chain cal-09780924943,

NIPERites: The system of nomenclature (naming) for organisms used today was established in 1735 by Carolus Linnaeus,

domain:-

it is related to protein structure which is responsible for the function of that particular protein

 Rxn which yields predominantly one stereoisomer(or one pr of enantiomers) of several possible diastereomers-STEREOSELECTIVE RXN

VNGoyani: Intestinal microbes synthesize:

> Vitamin B12

> biotin

> pantothenic acid

> vit.K

do named reactions fm Kalsi and Morrision n boyd. cell culture nd growth of bacteria fm micro part. and ask any querries regarding niper

SQC stands for

a)Standard quality control

b)Statistical quality control

c)Specific quality control

d) none

B

) Resolution of amino acid racemic mixture using hog kidney acylase is ____  resolution.

a)destructive

b)kinetic

c)both a n b

d)none of the

Kauntay: Photosensitization:-

A molecule in an excited state may transfer its all excess energy at a time to a different compound in the same enviro

Central rice research institute is located in -Orissa

Accelerated stability study is done at 40 C & 75% RH

Back titration,

acid base indicators,

Clinical trial details,

Ramchandran plot,

Nogami plot,

IR,NMR values,

VNGoyani: Correction:

Which instrument is not possible

A) FT-NMR

B) FT-UV

C) FT-IR

D)All are possible

NIPERites: free trade port=kandla

Rmchndrn plot=2 structure

Rectal suppository=2g

read types of stomata,excipients frm Remington

bepotastine ophthalmic solution is an antihistamine and mast cell stabilizer for treatment of the symptoms of allergic conjunctivitis.

Important synonyms for NIPER

Aborigine-Primitive inhabitant

Abortive-Unsuccessful

Abstinence-Restrained eating or drinking

All r included in N-

Hexahelicene shows chirality due to ________.

a)chiral axis

b)helical shape

c)chiral point

d)chiral carbon

Coumarin glycosides are derivative of

a)Benzo- alpha Pyrone

b)benzo- beta Pyrone

c)Lactone

d)none

VNGoyani: 2nd generation

Atazanavir

Darunavir

Tipranavir

Raltegravir belongs to which class of anti HIV?

ans.Integrase inhibitors

US FDA approved Edurant (rilpivirine)for treatment of HIV-1 infection in adults who never took HIV therapy.Do newly approved drugs for NIPER

USA is the highest cotton producing country (EVANS)

.gamma cyclodextrin is mos soluble

1-beta is called power of test in hypothesis testing.bst

PFK is activated by

a)fructose 2,6 - bisphosphate

b)ATP

c)both

d) only (a)

Biochemical target in pharmaceutical lead discovery may be

a)Enzymes

b)Receptor

c)Ion channels

d)All of these

Mohit@NIPER: read abt crystal habit,polymorphism,Amorphorphous forms,Viscosity(types os flow) from CVS or Martin.softwares names n uses from Foye

Pseudomembrane colitis is adverse effect of

a)chloramphenicol

b)streptogramins

c)clindamycin

d)none

For non-dissolution rate absorption the IDR value must be more than 1gm/cm2/sec

mercury is used for measuring granule density

FT- NMR used in

a)Change in frequency to time data

b)Change in time to frequency data

c)both  a &  b

d)none of these

C

Denosumab:RANK ligand inhibitor indicated 4 prevention of skeletal-related events in patients with bone metastases from solid tumors

 read briefly abt Cyclodextrin,complexation from Martin,seive sizes, sterilization conditions,Cell organells,Nobel prizes from Bio/Med f

 saxagliptin:

dipeptidyl peptidase-4 (DPP-4) inhibitor Use for the treatment of type 2 diabetes.

New drug for niper-jee 2011

Liebig -Pregl Method for determination of carbon and hydrogen

Zero dipole moment-carbon tetrachloride, methane,carbon dioxide.

mportant synonyms for NIPER

Aborigine-Primitive inhabitant

Abortive-Unsuccessful

Abstinence-Restrained eating or drinking

gods own country - kerala

indigen is part of which pharma giant?find

no of rabbits for sterility testing find?

SEZ-specisl economic zone.bst lu

Abzyme=antibody hving catalytic activity.

Totipotency=ability of single cell to divide&produce all differentiated cell in organism

Cedar wood oil is used in .......Magnification

a)4x¿

b)10x

c)40x

d)100x

D

NIPERs favourite topics:

receptors

Stereo

Marine drugs,clove,taxol

mass,ir,uv,nmr,cd

chromatography

rules of chemistry,biomole

cal us for m

Watson & ....... Announced discovery of DNA structure in.......

a)Sanger,1960

b)Crick,1953

c)Crick,1960

d)Sanger,1953

ans: B

NIPERites: Disintegrent is not used in

a) Buccal b) Sublingual c) Coated tablet d) all

Ans=b.

 vilazodon use for major depressive disorder.

spinosad is pediculicide indicated for the topical treatment of head lice infestations

FT- NMR used in

a)Change in frequency to time data

b)Change in time to frequency data

c)both  a &  b

d)none of these

C

NIPERites: What is the total number of pi bonds found in the 1-nitro propyne?

a) 1

b) 3

c) 2

d) 4

ans.d

: Investigational New Drug Application-for newly synthesized molecule after testing safty in animals,i.e.preclinical studies.

Find the missing number 10, 67, 130, 223, ?

a) 352

b) 357

c) 348

d) 373

ans: c

IDIOSYNCRACY (type-B ADR)

chloramphenicol-aplastic anaemia

primaqine-heamolysis

diclofenac-kidney damage

streptomycin-kidney damage

read in r

Orientation in Baroda on 4th

Rushinad classes,

Karamdham 3rd floor,

Productivity road

Akota.

elimumab:

B-lymphocyte stimulator (BLyS)-specific inhibitor indicated for the treatment of Systemic Lupus Erythematosus

Carbon free radical is sp2 hybridized

3>2>1>methyl

Overall carbocation stability:

3>1 benzyl>1 allyl>2>1>vinyl>methyl

Microdosing is directly given to patient without preclinical testing in which phase

a)0 Phase

b)I Phase

c)II Phase¿

d)III Phase

A

PHARMAGLIMPS-2

Aspartame, which is a synthetic sweetener is

a) dipeptide

b) tripeptide

c) lipidic substance

d) none

For absorption of iron, ferric ion is converted into

a)Fe+2

b)Fe+1

c)both

d) only (a)

HTS means

a)High throughput screening

b)Herbal Therapeutic survey

c)Both a & b

d)none of these

pharmaosmosis

what is the effect of polymer on glass transition temperature?

a. increase

b. decrease

c.no change

d. cant say

ans-A

VNGoyani: 4.Esomeprazole

5.Amlodipine

6.Infliximab, J&J

7.Etanercept

8.Olanzapine,eli lili

The synonym of abduct

a)Confined

b)Bound

c)Released

d)absolve

ans: A

VNGoyani: Also some topic should be om tip of tongue are:

New approved drugs,

Name of nobel prize winner,

Cology classification,

name reaction

In Markonikov's Rule, the intermediate formed is

a) carbanion

b) carbocation

c) free radical

d) all

Target

VANDETANIB:kinase inhbtr..Treat THYROID CANCER.

Ulman rxn: SYN OF DIPHENYL AMINE,DIPHENYL ETHERS,DIPHENYLS.

Zeta potential determined by micro electrophoresis, electro-osmosis, sedimentation potential or streaming potential.

gamma cyclodextrin has higher water solubility & does not cause nephrotoxicity & has largest cavity

fidaxomicin is a macrolide antibacterial drug indicated for the treatment of Clostridium difficile-associated diarrhea.

NIPERites: When product patent started in India?

A) 2003 B) 2005 C) 2009 D) 1985

Ans 2005

VNGoyani: TOP 10 Selling drug:

1: Lipitor (Atorvastatin) pfizer

2:Advair, Seretide(Fluticasone + Salmeterol) GSK

3:Plavix(Clopidogrel) BMS

pharmexcel

Samir: 2+3=30

7+2=126

6+5=330

8+4=384

Then

9+7=??

Ans:1008

(2+3)*(2*3)=30

(7+2)*(7*2)=126

(6+5)*(6*5)=330

(8+4)*(8*4)=384

So,(9+7)*(9*7)=1

HARISHARORA

An anticancer agent derived from an amino acid (phenylalanine) is a) busulphan b) malphalen c) thiotepa d) lomustine e) mesna.

PHARMAPOINT

Evaporation rates at Room Temp.

Ether >acetone >chloroform >CCl4 >ethyl acetate >water.

#Plz sms any pharma news to 09503748384-Guru.

pharmaosmosis

indian partnership ct 1932

indian tax act-1956

current 5 year planning is 11th nd will end in 2012

benting discovered insulin,sanger gave srctu

Which one the following is haemopoietic factor/s

a)Epoetin

b)Filgarstim

c)molgramostin

d)all

Join best N_pac

GATEPY2009

NAA: Solvents used in IR:

non-aqeous: CHCl3,CS2,CCl4

Nujol shows absorption at: 719,1376,1462,2915 cm-1

plz do IR ranges(near,mid,far),UV,NMR.

GUNTURACADEMY

Rajesh: Long actng statin:ATORVASTATIN.Best drug..Lepitor brand name..Synthetic pentasacharide heparin fragment:FONDAPARINASE[Ad] Cashless Treatment in 800 Cities! SMS APL to 56070

pharmexcel

VNGoyani: One of the following is aprotic solvent

a) Dimethylsulfoxide (DMSO)

b) Dimethyl formamide

c) Hexamethylphosphorotriamide (HMPT)

d)

pharmaosmosis

ferquently askes name rxn:

curtuis,Wittig,chichibhabin,makoniokov,kharash,calsen,clemmenson,zeisels,shapiro,suzuki,negishi,ozonolysis,grignard et

pharmexcel

VNGoyani: Which is biggest cotton producing country in the world?

a)India

b)China

c)Pakistan

d)Shrilanka

4 such GK question

ON 4success

Chronic candidiasis infections of G.I. tract & oral cavity treated orally with

a)Amphotericin B

b)Nystatin

c)Miconazole

d)Fluconazole

GUNTURACADEMY

Rajesh: Minister of chemicals&fertilizers of central govt:ALAGIRI..Aspargine:N,glutamine-Q,lysine-k,Aspartic acid:D,glutamic a'-E,Tryptophan:W

Active form of artemisinin:DIHYDRO ARTEMESININ..Side eft:NEUTROPENIA..Doc 4 CEREBRAL MALARIA..AMES,CHROMOSOMAL ABERATN TEST:Mutagenicity.

[Ad] Cashless Treatment in 800 Cities! SMS APL to 56070

drug receptor interaction is a exothermic reaction.

first planning commission set up in 1950 nd fist plan in 1951.

Jacob nd monad -lac operon co

Threose and Erythrose are

a) Diastereomer

b) Enantiomer

c) syn isomer

d) anti isomer

Matrix in MALDI - Benzoic,cinnamic,cinapinic etc.

MS MS -s MAss spectrometers in series.

Which is endogenous anticonvulsant?

find.

read abt va

PHARMAGLIMPS-2

Tartaric Acid is

A.2,3 Dihydroxy butane dioic acid         

B.1,2 Dihydroxy butane dioic acid                

C.1,3 Dihydroxy butane dioic

pharmexcel

VNGoyani: boceprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated for the treatment of chronic hepatitis C.

Highest first pass metabolism shown by-

verapamil,

propranolol,

propoxyphen,

pethidine,

methyl testosteron,

salbutamol,

nitroglycerin.

-Have

VNGoyani: Phenomenon of introduction of DNA into host bacteria is called:

a)Transversion

b)translocation

c)Transformation

d)Transduction

ans:

Peptic ulcer is need to be treated using Antibiotics Only if it is caused by microbes like Hellicobacter Pylori.

# # # # # #

HARISHARORA

if GLARE is coded as 67810 & MANSOON as 2395339 then how can

RANSOM be coded

a)183952

b)198532

c)189352

d)189532.my best wishes wid u all

PHARMAGLIMPS

Psychrometric chart is related to

a)Osmotic pressure

b)Humidity

c)solubility

d) evaporation

B

Choose best option for ur future

pharmaglimps.

pharmaosmosis

trde name

binders:

luvitec:PVP

Walocel:HPMC

diluents:

cel-tab:Cal. carbonate + malto dextrins

Di-Pac-sucrose+maltodextrins.all dis in our po

1)Clinistrips test quantitatively test for sugar in urine.

2)The Kastle-Meyer test tests for the presence of blood

call 07814564264 for any quer

PHARMAGLIMPS

Dielectric const. of water at 250C is

a) 78.5

b) 56.5

c) 78.0

d) 77.5

Mutually exclusive events have probabaility 1.

If there is meso formation the no. of isomers is equal to less than 2^n

read about crams rule

VNGoyani: IUPAC name, solvent propery,solubility order, bonding, chemistry of protein and carbohydrates, reaction order, physiochemical property

PHARMAGLIMPS-2

quinidine dextroisomer -antiarrythmatic,

quinine ievo isomer- antimalarial

cold creams -W/O emulsion

vanishing cream - O/W emulsion

078145642

PHARMAGLIMPS-2

CH3-CH=CH2+HBr

a)CH3-CH2-CH2Br

b)CH3-CHBr-CH3

c)CH2Br-CH2Br-CH3

d) BrCH2-CH2-CH2Br

See anti Markovnikov addition

Best NIPER-pack at ur door

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 WIPO-WORLD INTELLECTUAL PROPERTY ORGANISATION..Comb of circular dichroism&circular bifrigence:COTTON EFFECT..All enzymes r CHIRAL.

GATEPY2009

NAA: BT is used as opposed to standard volumetric titration when the substance being analyzed is either too weak to give a valid reaction

GATEPY2009

Mohit@NIPER: Drugs producing St.Johnsn Synd:

S:Sulphonamide

A:Amprenavir

F:Fluconazole

I:Itraconazole

T:Thiabendazole

HARISHARORA

"HENBANE"  is the common name of a) stramonium b) hyoscyamus c) belladona d) cinchona.send ON PHARMATRAIN to 9870807070

VNGoyani: All of the following are stop codon except

a)UGA

b)UGC

c)UAG

d)AUG

Do DNA replication,translation from styanarayan.

ans:b

# Remember all schedules in D&C act.

# ART drugs (drugs used in HIV infection).

# do drug classification from book by Vikas seth.

>GUD MORNing<

______ is optically active.

a) glucose

b)2-bromobutanol

c)D-glyceraldehydeç

d) All of the above

IMP FOR NIPER:biostatistics, nobel prize winner in Medicine, imp GK, Recent FDA approvals & pharma news, imp full forms, imp govt institutes.